<\/noscript>C\u00e9sar Milstein naci\u00f3 en Bah\u00eda Blanca, Argentina en el a\u00f1o 1927 y muri\u00f3 en Cambridge, Reino Unido en el 2002. Fue un bioqu\u00edmico argentino. Se licenci\u00f3 en qu\u00edmica en la Universidad de Buenos Aires en 1957 y, tras realizar su tesis doctoral en el departamento de qu\u00edmica biol\u00f3gica de la Facultad de Medicina, bajo la supervisi\u00f3n de Andr\u00e9s Stoppani, obtuvo una beca del Consejo Brit\u00e1nico para continuar sus investigaciones en Cambridge.<\/p>\nEn 1962 regres\u00f3 al pa\u00eds y asumi\u00f3 la direcci\u00f3n de la divisi\u00f3n de biolog\u00eda molecular del Instituto Nacional de Microbiolog\u00eda Malbr\u00e1n. Pero los cambios pol\u00edticos motivaron la intervenci\u00f3n del Instituto Malbr\u00e1n y la remoci\u00f3n de su director y de los principales investigadores de su plantel. Milstein decidi\u00f3 entonces regresar a Cambridge, incorpor\u00e1ndose al laboratorio de biolog\u00eda molecular del Medical Research Council como docente e investigador.<\/p>\nEn 1984, Milstein comparti\u00f3 el premio Nobel de Fisiolog\u00eda y Medicina con el brit\u00e1nico Niels K. Jerne y el alem\u00e1n Georg K\u00f6lhler, por sus trabajos en el desarrollo de anticuerpos monoclonales como especies moleculares puras. Recibi\u00f3 adem\u00e1s los premios Konex de 1993 y Konex de brillante en ciencia y tecnolog\u00eda.<\/p>\nMilstein investig\u00f3 la estructura de un anticuerpo y su correspondiente ARN mensajero, dando paso con estos estudios al descubrimiento de los anticuerpos monoclonales. Estos anticuerpos est\u00e1n producidos por c\u00e9lulas monoclonales y son qu\u00edmicamente puros. Milstein y G. K\u00f6lhler elaboraron un m\u00e9todo para la diagnosis cl\u00ednica y los ensayos en el que tales c\u00e9lulas son imprescindibles.<\/p>\nEste m\u00e9todo se utiliza habitualmente en el Reino Unido para la determinaci\u00f3n del grupo sangu\u00edneo, a la hora de realizar una transfusi\u00f3n. De esta forma un MCA contra el ant\u00edgeno rhesus-D puede ser empleado en mujeres embarazadas Rh negativo cuando el feto es Rh positivo. El descubrimiento de los MCA fue un avance muy importante para la investigaci\u00f3n biol\u00f3gica, para el diagn\u00f3stico cl\u00ednico y, probablemente, para el tratamiento de muchas enfermedades, entre las que se encuentran algunos tipos de c\u00e1ncer.<\/p>\nLos hallazgos de Milstein y su grupo de investigadores tuvieron el prop\u00f3sito inicial de resolver problemas de inmunolog\u00eda b\u00e1sica, pero inmediatamente encontraron otras aplicaciones. En pocos a\u00f1os han servido para preparar anticuerpos monoclonales contra una gran variedad de sustancias, y se los utiliza adem\u00e1s en el diagn\u00f3stico de enfermedades y en la tipificaci\u00f3n de grupos sangu\u00edneos y de ant\u00edgenos de histocompatibilidad, as\u00ed como en procesos de purificaci\u00f3n de diversos productos de la industria farmacoqu\u00edmica.<\/p>\n\nEntrevista a Cesar Milstein 1<\/a><\/li>\n2<\/a><\/li>\n3<\/a><\/li>\n4<\/a><\/li>\n5<\/a><\/li>\n6<\/a><\/li>\n<\/ul>\n\n\nEntrevista a Cesar Milstein 1<\/b><\/span><\/p>\n<\/object><\/p>\n<\/div>\n\n\n2<\/b><\/span><\/p>\n<\/object><\/p>\n<\/div>\n\n\n3<\/b><\/span><\/p>\n<\/object><\/p>\n<\/div>\n\n\n4<\/b><\/span><\/p>\n<\/object><\/p>\n<\/div>\n\n\n5<\/b><\/span><\/p>\n<\/object><\/p>\n<\/div>\n\n\n6<\/b><\/span><\/p>\n<\/object><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"C\u00e9sar Milstein fue un bioqu\u00edmico argentino. Se licenci\u00f3 en qu\u00edmica en la Universidad de Buenos Aires en 1957… Ver m\u00e1s…<\/a> <\/p>\n","protected":false},"author":6,"featured_media":176588,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8198],"tags":[11711,10555,11710,11709,786,370,11261,787],"class_list":{"0":"post-176587","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-multimedia","8":"tag-anticuerpo","9":"tag-argentino","10":"tag-arn","11":"tag-bioquimico","12":"tag-investigador","13":"tag-medicina","14":"tag-nobel","15":"tag-premio-nobel"},"_links":{"self":[{"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/posts\/176587","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/comments?post=176587"}],"version-history":[{"count":0,"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/posts\/176587\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/media\/176588"}],"wp:attachment":[{"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/media?parent=176587"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/categories?post=176587"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/tags?post=176587"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
En 1962 regres\u00f3 al pa\u00eds y asumi\u00f3 la direcci\u00f3n de la divisi\u00f3n de biolog\u00eda molecular del Instituto Nacional de Microbiolog\u00eda Malbr\u00e1n. Pero los cambios pol\u00edticos motivaron la intervenci\u00f3n del Instituto Malbr\u00e1n y la remoci\u00f3n de su director y de los principales investigadores de su plantel. Milstein decidi\u00f3 entonces regresar a Cambridge, incorpor\u00e1ndose al laboratorio de biolog\u00eda molecular del Medical Research Council como docente e investigador.<\/p>\n
En 1984, Milstein comparti\u00f3 el premio Nobel de Fisiolog\u00eda y Medicina con el brit\u00e1nico Niels K. Jerne y el alem\u00e1n Georg K\u00f6lhler, por sus trabajos en el desarrollo de anticuerpos monoclonales como especies moleculares puras. Recibi\u00f3 adem\u00e1s los premios Konex de 1993 y Konex de brillante en ciencia y tecnolog\u00eda.<\/p>\n
Milstein investig\u00f3 la estructura de un anticuerpo y su correspondiente ARN mensajero, dando paso con estos estudios al descubrimiento de los anticuerpos monoclonales. Estos anticuerpos est\u00e1n producidos por c\u00e9lulas monoclonales y son qu\u00edmicamente puros. Milstein y G. K\u00f6lhler elaboraron un m\u00e9todo para la diagnosis cl\u00ednica y los ensayos en el que tales c\u00e9lulas son imprescindibles.<\/p>\n
Este m\u00e9todo se utiliza habitualmente en el Reino Unido para la determinaci\u00f3n del grupo sangu\u00edneo, a la hora de realizar una transfusi\u00f3n. De esta forma un MCA contra el ant\u00edgeno rhesus-D puede ser empleado en mujeres embarazadas Rh negativo cuando el feto es Rh positivo. El descubrimiento de los MCA fue un avance muy importante para la investigaci\u00f3n biol\u00f3gica, para el diagn\u00f3stico cl\u00ednico y, probablemente, para el tratamiento de muchas enfermedades, entre las que se encuentran algunos tipos de c\u00e1ncer.<\/p>\n
Los hallazgos de Milstein y su grupo de investigadores tuvieron el prop\u00f3sito inicial de resolver problemas de inmunolog\u00eda b\u00e1sica, pero inmediatamente encontraron otras aplicaciones. En pocos a\u00f1os han servido para preparar anticuerpos monoclonales contra una gran variedad de sustancias, y se los utiliza adem\u00e1s en el diagn\u00f3stico de enfermedades y en la tipificaci\u00f3n de grupos sangu\u00edneos y de ant\u00edgenos de histocompatibilidad, as\u00ed como en procesos de purificaci\u00f3n de diversos productos de la industria farmacoqu\u00edmica.<\/p>\n
<\/object><\/p>\n<\/div>\n\n\n2<\/b><\/span><\/p>\n<\/object><\/p>\n<\/div>\n\n\n3<\/b><\/span><\/p>\n<\/object><\/p>\n<\/div>\n\n\n4<\/b><\/span><\/p>\n<\/object><\/p>\n<\/div>\n\n\n5<\/b><\/span><\/p>\n<\/object><\/p>\n<\/div>\n\n\n6<\/b><\/span><\/p>\n<\/object><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"C\u00e9sar Milstein fue un bioqu\u00edmico argentino. Se licenci\u00f3 en qu\u00edmica en la Universidad de Buenos Aires en 1957… Ver m\u00e1s…<\/a> <\/p>\n","protected":false},"author":6,"featured_media":176588,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8198],"tags":[11711,10555,11710,11709,786,370,11261,787],"class_list":{"0":"post-176587","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-multimedia","8":"tag-anticuerpo","9":"tag-argentino","10":"tag-arn","11":"tag-bioquimico","12":"tag-investigador","13":"tag-medicina","14":"tag-nobel","15":"tag-premio-nobel"},"_links":{"self":[{"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/posts\/176587","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/comments?post=176587"}],"version-history":[{"count":0,"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/posts\/176587\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/media\/176588"}],"wp:attachment":[{"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/media?parent=176587"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/categories?post=176587"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/tags?post=176587"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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<\/object><\/p>\n<\/div>\n\n\n3<\/b><\/span><\/p>\n<\/object><\/p>\n<\/div>\n\n\n4<\/b><\/span><\/p>\n<\/object><\/p>\n<\/div>\n\n\n5<\/b><\/span><\/p>\n<\/object><\/p>\n<\/div>\n\n\n6<\/b><\/span><\/p>\n<\/object><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"C\u00e9sar Milstein fue un bioqu\u00edmico argentino. Se licenci\u00f3 en qu\u00edmica en la Universidad de Buenos Aires en 1957… Ver m\u00e1s…<\/a> <\/p>\n","protected":false},"author":6,"featured_media":176588,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8198],"tags":[11711,10555,11710,11709,786,370,11261,787],"class_list":{"0":"post-176587","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-multimedia","8":"tag-anticuerpo","9":"tag-argentino","10":"tag-arn","11":"tag-bioquimico","12":"tag-investigador","13":"tag-medicina","14":"tag-nobel","15":"tag-premio-nobel"},"_links":{"self":[{"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/posts\/176587","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/comments?post=176587"}],"version-history":[{"count":0,"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/posts\/176587\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/media\/176588"}],"wp:attachment":[{"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/media?parent=176587"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/categories?post=176587"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/tags?post=176587"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/object><\/p>\n<\/div>\n\n\n4<\/b><\/span><\/p>\n<\/object><\/p>\n<\/div>\n\n\n5<\/b><\/span><\/p>\n<\/object><\/p>\n<\/div>\n\n\n6<\/b><\/span><\/p>\n<\/object><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"C\u00e9sar Milstein fue un bioqu\u00edmico argentino. Se licenci\u00f3 en qu\u00edmica en la Universidad de Buenos Aires en 1957… Ver m\u00e1s…<\/a> <\/p>\n","protected":false},"author":6,"featured_media":176588,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8198],"tags":[11711,10555,11710,11709,786,370,11261,787],"class_list":{"0":"post-176587","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-multimedia","8":"tag-anticuerpo","9":"tag-argentino","10":"tag-arn","11":"tag-bioquimico","12":"tag-investigador","13":"tag-medicina","14":"tag-nobel","15":"tag-premio-nobel"},"_links":{"self":[{"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/posts\/176587","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/comments?post=176587"}],"version-history":[{"count":0,"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/posts\/176587\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/media\/176588"}],"wp:attachment":[{"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/media?parent=176587"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/categories?post=176587"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/moonmentum.com\/blog\/wp-json\/wp\/v2\/tags?post=176587"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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![\"Cesar](\"http:\/\/www.moonmentum.com\/blog\/wp-content\/uploads\/2013\/10\/cesar-misltein.jpg\")